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Studies have reported that approximately 98% of the administered EC remains within the gut shortly after ingestion ( In a radiolabeled study using (2- 14 C)-EC in rats, less than 0.1% of the administered dose was detected in the brain, testes, spleen, heart, skeletal muscle, and lungs

Statements Author contributions YZ, W-QZ, and X-YLiu reviewed literature and originally drafted the manuscript

Qin J, Chai G, Brewer JM, Lovelace L, Lebioda L

Arch Toxicol 90(1):137 Woonciej M, Milewska E, Roszkowska-Jakimiec W (2016) Trace elements as an activator of antioxidant enzymes

Priority should be given to well-designed human intervention studies, integrate systems biology approaches, and explore delivery technologies that enhance the stability and targeted action of these molecules