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Surprisingly, however, mutant nox1 plants, which only accumulate 3040% more SNO than WT plants under basal conditions 26 , did not exhibit altered NR activity (Fig

10.3324/haematol.2014.114728 139

Caloric restriction trials have also demonstrated beneficial effects on methylation at age-related CpG sites, suggesting diet-related modulation of aging pathways [15]