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Under current US compounding rules, pharmacies and outsourcing facilities may only compound medicines using active pharmaceutical ingredients (bulk drug substances) that form part of an FDA-approved medicine, appear in an official United States Pharmacopeia or National Formulary monograph, or are included on the FDAs bulk drug substance list

Further to this, muscle damage and subsequent repair are accompanied by the recruiting of phagocytic cells and macrophages which are additional sources of ROS generation leading to damage of the musculature itself and muscle impairment

The supplement requires the company to update its labeling to include the risk of thrombotic microangiopathy, in which blood clots may form in blood vessels, restricting blood flow and causing organ damage

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Any theoretical desensitization at one receptor type would not affect the others