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5.3 Toll-like Receptor (TLR) ligand-mediated signalling pathways When peritoneal injury and oxidative stress occurs in PMCs, nuclear high mobility group box 1 (HMGB1) protein, a DAMP, leaks out of the cells

Chen Q, Shou P, Zheng C, Jiang M, Cao G, Yang Q, Cao J, Xie N, Velletri T, Zhang X, Xu C, Zhang L, Yang H, Hou J, Wang Y, Shi Y

(2006) Phase II combined biological therapy targeting the HER2 proto-oncogene and the vascular endothelial growth factor using trastuzumab (T) and bevacizumab (B) as first line treatment of HER2-amplified breast cancer

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In contrast to other carotenoids, this lipophilic acyclic isomer of b-carotene lacks vitamin A activity and, although it represents the most predominant carotenoid in human plasma that is enriched in (very-) low-density lipoprotein fractions