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In addition, it acts on the process known as angiogenesis, which helps new blood vessels to form via existing blood vessels

Science 355 , 13061311 (2017)

Moreover, IGFBP-3 has been claimed to provide information about IGF-I bioavailability from calculating the molar ratio of total IGF-I to IGFBP-3

Researchers note that intranasal delivery may especially increase the bioavailability of peptide therapeutics and present an appealing alternative to injection [14, 15, 16]