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In this study, 75% of patients had high IFN signature at baseline

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On the other hand, once the sonosensitizer ILD and immune agonist R848 co-encapsulated nanoprobe targets the tumor site, the small to large transition may be triggered by the acidic microenvironment, which further accelerates drug release owing to the enhanced cavitation effect under low-frequency ultrasound (LFUS) irradiation