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Only with the recent development of locus-targeted tools, such as clustered regularly interspaced short palindromic repeats (CRISPR-Cas9) or transcription activator-like effector nucleases-based epigenetic editors, has it become feasible to directly test how defined chromatin or methylation changes influence neural and behavioral outcomes 9,183,184

Eur J Pharmacol 15(881):173282 Hrushesky WJ, Lis CG, Levin RD, Grutsch JF, Birdsall T, Wood PA, Huff DF, Reynolds JL et al (2022) Daily evening melatonin prolongs survival among patients with advanced non-small-cell lung cancer

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He L, Zhang F, Jian Z, Sun J, Chen J, Liapao V, et al

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