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The clinical spectrum of irAE is broad and can affect multiple organ systems (Figure 2)

Mps one binder 1 (MOB1), an essential component of the Hippo signaling pathway, is phosphorylated by mammalian STE20-like protein kinase 1/2 (MST1/2) and enhances the activity of large tumor suppressor kinase 1/2 (LATS1/2) (103)

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However, preliminary tumor tissue analysis showed downregulation of 12 cell cycle-related genes and nine apoptosis-related genes in the treatment group compared with the placebo

Materials and Methods UGT74F1 and UGT74F2 expression in Escherichia coli Codon optimized genes for UGT74F1 and UGT74F2 were ordered from Genscript and cloned into pET15(+)b with a thrombin-cleavable N-terminal hexa-histidine tag