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Repeated IV/IM doses indeed suggested efficacy for DFO in Alzheimers disease, but such invasive regimens are not practical long-term and carry significant risks

doi:10.1038/srep32734

The only exception is the mitochondria present in the heart of rat.33 This implies that the breakdown of hydrogen peroxide to water and oxygen is carried out by another enzyme known as glutathione peroxidase in mammalian cell mitochondria

Interestingly, HO-1 induction and CO generation were reported to promote the repair of DNA double strand breaks presumably via ATM as shown in Hmox-1 / mice and fibroblasts derived thereof 55

Colombo MG, Raposo C, Thry