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and (2) directly binding to mono-ubiquitin to mask mono-ubiquitin activating sites such as Glu64, Phe4, Leu8 and Leu43 (Nakatsu et al., 2000

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Given these pronounced differences in cluster composition between WT and KO (Supplementary Fig

CulkinsCAdomanisRPhanNRobinsonBSlatonELothropEet alUnlocking the gates: therapeutic agents for noninvasive drug delivery across the blood-brain barrier