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Male microbiota-associated metabolite restores macrophage efferocytosis in female lupus-prone mice via activation of PPAR/LXR signaling pathways

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For example, a modified DNA peptide therapy targeting pro-inflammatory interleukin (IL)-17 significantly reduced organ damage and increased the survival of treated lupus-prone mice, [48] while targeting the CXC chemokine ligand 10 (CXCL10) attenuated experimental autoimmune encephalomyelitis

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BPC-157 has been discussed by the FDA in the context of bulk drug substances that may present significant safety risks, and TB-500 is generally promoted in research-peptide settings rather than as an FDA-approved therapeutic product