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Melatonin, for instance, has been shown to activate the PKC/Nrf2 signaling cascade, upregulate the anti-apoptotic protein BCL-xL, suppress cytochrome c release, and inhibit mitochondrial-dependent apoptotic pathways

FEBS Lett 2011, 585: 37703780

Bouyahya A, Chamkhi I, Balahbib A, Rebezov M, Shariati MA, Wilairatana P, Mubarak MS, Benali T, El Omari N (2022) Mechanisms, anti-quorum-sensing actions, and clinical trials of medicinal plant bioactive compounds against bacteria: a comprehensive review

As the upstream RLuc reporter is translated by cap-dependent scanning 58 , which is reported to be enhanced in YBX1 deficiency 59 , to compare the translational efficiency of the PRKAA1 5UTR in shCtrl and shGDH1 or shYBX1 cells, the FLuc activity of the empty reporter group was used for normalization, as previously described 38

Clinical safety data from phase II trials for inflammatory bowel disease show BPC-157 exhibited particular wound healing effects with no reported toxicity