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In fact, it has been shown that in human liver cells as much as 50% of the cysteine in glutathione is derived from Hcy (Mosharov et al., hyperhomocysteinemia ought to be protective toward GSH, or in other words, that vitamin B 12 deficiency actually has antioxidant benefit

J Hepatol 2013;58:15568

22,169 conducted a comprehensive analysis of 107 Mendelian randomization studies, included a median of 7,158 participants and 2,225 cases, with serum uric acid level as the exposure variable for various health outcomes