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This was confirmed by preincubation of (2 S ,3 S )- t -ES- a9 - b7 with cathepsin B for 30 min at ten times the IC 50 , which completely inactivated cathepsin B when assayed with fluorogenic substrate following 100-fold dilution 57 (Supplementary Fig

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So, helminths intervene from the first events in immune recognition to favour the development of a regulatory environment in which host and parasite can remain in a long-term homeostatic relationship

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The D-amino acid substitution preserves the spatial orientation of amino acid side chains needed for competitive binding to the FOXO4-p53 interaction surface, maintaining biological activity despite the non-natural backbone (PMID: 28340339)