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In fact, the use of GSTP1 knockout mice demonstrated that loss of GSTP1 expression increases sensitivity to metabolic or environmental toxins and promotes mutations and cancer development ( FIGURE 2 Prostate cancer Promoter hypermethylation leading to epigenetic silencing of GSTP1 gene expression is frequently detected in prostate cancer cells, the most commonly diagnosed type of malignancy among men in Western European countries and the second cause of cancer-related deaths among men worldwide ( Figure 2 )

This in turn requires the availability of reliable tools for confirming the diagnosis of OS and evaluation its severity

Kumar SK, Lee JH, Lahuerta JJ, Morgan G, Richardson PG, Crowley J et al

These findings suggest a strong association between alcohol intake, sleep disorders, and astrocytic gliotransmission

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