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Morphologically, the mitochondria are smaller with an increase in mitochondrial membrane density and reduction or disappearance of mitochondrial cristae as well as rupture of the outer mitochondrial membrane, but the nuclear size is intact ( c -glutathione (GSH)glutathione peroxidase 4 (GPX4) axis, the elevation of iron metabolism axis, and the lipid metabolism (Figure 1)

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J Inorg Biochem 85:209217 Suryadi J, Bierbach U (2012) DNA metalating-intercalating hybrid agents for the treatment of chemoresistant cancers