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A multiple imputation approach was used to handle missing data 31 , with imputation based on available data from participants in the same treatment arm with the same treatment status (on-treatment or discontinued)

It is listed as a rare adverse reaction in UK product information for both oral and injectable B12 preparations, and most people tolerate B12 supplements well even at high doses

B12 doses ranging from 500-1000 mcg, with methionine, inositol, and choline ratios adjusted per formula

The availability of compounded tirzepatide has democratized access to this medication, though researchers should verify source quality and testing standards

Images of oil red O staining in control and inhibitor-treated cells were digitally photographed using a light microscope (Olympus BX41