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Mice were divided into six groups (with six male and six female mice in each group): control, mice treated with 100 mg/kg ALCAR, mice treated with low and high doses of Al 2 O 3 NPs, mice treated with a low dose of Al 2 O 3 NPs + 100 mg/kg ALCAR, and mice treated with a high dose of Al 2 O 3 NPs + 100 mg/kg ALCAR

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The peptide powerfully modulates inflammation by increasing microRNA-146a expression while decreasing pro-inflammatory cytokines including TNF-alpha, IL-6, IRAK1, and TRAF6

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