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NAC-derived cysteine is metabolized by three O 2 -independent enzyme systems: cystathionine -synthase ( CBS) condenses cysteine and homocysteine to generate cystathionine and H 2 S

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Conflict of interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper

The duration of effect of fentanyl was defined as the time interval from the time of injection of fentanyl administration to the recovery of righting reflex