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Surv Ophthalmol 2008, 53 Suppl1:S3-10

Loss of Von Hippel-Lindau (VHL) tumor suppressor gene function: VHL-HIF pathway and advances in treatments for metastatic renal cell carcinoma (RCC)

Through these two distinct types of interactions, the unliganded L1 domain effectively bridges the two legs of the active IGF1R dimer and brings them into close proximity for receptor activation (Fig

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