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Boss et al., U.S

For example, by removing Na+ from the xylem, data has shown that the K+ concentration in the xylem sap is larger in wildtype controls than in hkt1 mutants in Arabidopsis, presumably due to HKT1-dependent Na+ mediated depolarisation and the ensuing K+ efflux from xylem parenchyma cells

Mutat Res 2001

4(7):a020636

The review also discusses the challenges in targeting 7nAChR and its implications for medication development and prospective avenues for further investigation