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Together, these findings suggest that inhibiting ferroptosis is a potential treatment for I/R or LPS-induced ALI

Abbreviations ARDS: Acute respiratory distress syndrome AUROC: Area under the receiver operating characteristic curve CO: Cardiac output CVP: Central venous pressure CRT: Capillary refill time EVLW: Extravascular lung water IAP: Intra-abdominal pressure ICU: Intensive care unit IVC: Inferior vena cava LV: Left ventricular LVEF: Left ventricular ejection fraction MAP: Mean arterial pressure PAC: Pulmonary artery catheter P a O 2 /F i O 2 : Ratio of the arterial oxygen partial pressure over the inspired oxygen fraction PCO 2 : Partial pressure of carbon dioxide PLR: Passive leg raising PVPI: Pulmonary vascular permeability index RCT: Randomized controlled trial RV: Right ventricular SVV: Stroke volume variation SvO 2 : Venous oxygen saturation VA ECMO: Veno-arterial extracorporeal membrane oxygenation VExUS: Venous excess by ultrasound score References Vincent JL, De Backer D (2013) Circulatory shock

1 Confirmation of ALDH2 deletion in various strains of single organ Aldh2 KO mice

Growth factors and diabetic neuropathy