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Intervertebral disc disease often involves neuropathic pain components, which could benefit from drugs that influence NMDA receptor activity [24, 25]

Today, peptide therapy has evolved into a sophisticated field that harnesses these molecular messengers to address various health conditions, particularly chronic pain and injury recovery

The initial research was almost exclusively focused on its cytoprotective and healing effects within the gastrointestinal tract

Peptides work as signaling molecules and regulate physiological processes

For example, the minimally invasive needle IVD puncture procedure in rats aimed to model CDLBP, demonstrated that these animals developed pain based on a reduction of distance covered in the open field testing, inhibited rearing positions and twitching as compared to control sham animals