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lower, optimal-dose anti-angiogenic treatment could be more advantageous than higher-dose therapy to establish a favorable TME leading to the therapeutic benefit

The initial dose in children is 400 (300-500) mg/kg body weight given intravenously as indicated above

[PubMed] [Google Scholar] Kranich, O

Thus, the lack of post-treatment alteration in plasma BCAA concentration could be attributed to the effect of glycine supplementation on BCAA metabolism in different organs