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And it is very rare

Brief report: High frequency of biochemical markers for mitochondrial dysfunction in autism: no association with the mitochondrial aspartate/glutamate carrier SLC25A12 gene

Studies have demonstrated that CNNM4 expression is markedly upregulated in liver tissues from patients and experimental models of MASH (8), DILI (6), and ALD (12), with expression levels correlating closely with disease severity

This effect may result from the activation of the HIF-1/VEGF-A/VEGFR1 signaling pathways and the promotion of the endogenous antioxidant superoxide dismutase 2 (SOD2) expression [342]

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