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It was demonstrated that HG could cause the early activation of caspase-3/7 in SCs in vitro and in vivo , inducing caspase-dependent apoptosis in SCs ( in vivo study demonstrated that the apoptosis rate of RSC96 cells treated with HG for 48 h was increased by 9.72-fold, confirming that high glucose also elevated the mitochondrial pathway apoptosis-related Bax/Bcl-2 and cleaved caspase-9/caspase-9 ratios, and suggested that knockdown of histone deacetylase (HDAC1) could effectively inhibit HG-promoted mitochondrial apoptosis ( In addition to the above regulatory pathways, the role of HG on signaling pathways is critical in inducing apoptosis in SCs

Oncogene (2007) 26(22):310012

Your dentist may recommend it in some instances.

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In mixed contaminant systems, heavy metals enhanced the adsorption of antibiotics, whereas antibiotics had a minimal effect on heavy metal adsorption