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In vitro and in vivo experimental studies suggested that HDL associated-PON1 inhibited LDL-oxidation by catalyzing the breakdown of oxidized phospholipids, thus abolishing the production of pro-inflammatory cytokines (MCP-1, IL-8 and macrophage colony stimulating factor) from ECs (216220)

This study demonstrates that a three-month treatment with methylcobalamin and folinic acid is associated with significant improvements in behavioral symptoms associated with autism spectrum disorder in a group of children with autistic disorder and metabolic markers of abnormal redox and methylation metabolism

The primary endpoint was HbA1c change from baseline to 24 weeks, and secondary endpoints included change in HbA1c and bodyweight at 36 weeks

doi: 10.1038/s41398-023-02524-0

J Histochem Cytochem