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doi: 10.1016/j.cbi.2025.111632 32 CheffD MHuangCScholzenK CGenchevaRRonzettiM HChengQet al

Dysfunction of E3 ubiquitin ligases has a close relationship with mitochondrial defects and disruption of protein degradation

This vibration then causes the ossicles to move, and ultimately shifts fluids within the cochlea

Furthermore, GPX4 deficient mice are associated with increased interstitial oedema and tubular cell death, suggesting a critical role for GPX4 in mediating renal tubular injury (132)

Paired pulse plasticity was evaluated with varying inter-stimulus intervals and showed that neurons expressing Munc18-1 Q301D had significantly higher paired pulse ratio compared with neurons expressing Munc18-1 Q301R at intervals of 20, 100, and 200 ms and compared with neurons expressing Munc18-1 wt at intervals of 10 and 200 ms (Fig