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Leishmania species ( FIGURE 1 To minimize side-effects, enhance the therapeutic effect, and reduce the emergence of parasite resistance, binary combinations between two of these approved drugs have been employed in specific regions with epidemic situations in Africa and Asia

Jayakumar T, Hsieh CY, Lee JJ, Sheu JR (2013) Experimental and clinical pharmacology of Andrographis paniculata and its major bioactive phytoconstituent andrographolide

Excessive neuronal iron promotes NFT formation via the activation of CDK5 (Cyclin-dependent kinase 5)/P25 complexes and GSK-3 (Glycogen synthase kinase-3 beta) kinase pathways