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Nrf2, which can induce the expression of phase II detoxifying enzyme-encoding genes through antioxidant response elements (AREs), was defined as a master regulator of antioxidant systems in 1997

IRS2, Insulin receptor substrate 2

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Chronic GPER1 activation protects against oxidative stress-induced cardiomyoblast death via preservation of mitochondrial integrity and deactivation of mammalian sterile-20-like kinase/yes-associated protein pathway

Adults have a relatively stable gut microbiota, but long-term dietary changes, medication use, and other diseases can have a disruptive effect