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In addition, in a pig model, Lactobacillus reuteri XL0930 in the gut microbiota reduced muscle carnitine levels and promoted fatty acid deposition by downregulating SLC22A5 in muscle tissue [253]

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Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow

Immune homeostasis dysregulation and autoimmunity risk: as CUL5 is a key negative feedback regulator of both T-cell receptor (TCR) and cytokine signaling pathways ( in vivo cell therapies is achieving controllable, reversible, and spatiotemporally specific regulation of CUL5 expression or activity (203)