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The p53(3KR) mutant, lacking acetylation due to lysine-to-arginine substitutions at three residues, decreases expression of SLC7A11 without affecting other p53 targets such as CDKN1A/p21 (involved in cell cycle progression) or BAX (involved in apoptosis)

By formulating Pluronic F127 below its critical gelling concentration (CGC) in a hypotonic vehicle, application to the ocular surface led to the formation of a thin, uniform, drug-laden gel layer [20]

Sitting for extended periods, hunching over phones or computers, and sleeping in awkward positions all contribute to chronic strain

This mixture was heated to 130 C for 15 h and then cooled to room temperature 69

Contraindications Contraindications have not been identified