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A recent study indicated that BTB and CNC homology 1 (BACH1, a heme-binding transcription factor required for the regulation of oxidative stress and metabolic pathways associated with heme and iron), suppresses GSH synthesis pathway-related genes such as GCLM and GCLC to reduce GSH and regulate ferroptosis (Igarashi and Watanabe-Matsui, 2014

In most nutritional studies with fish, authors did not determine the concentrations of creatine and its metabolites in skeletal muscle and other tissues (e.g., [42,43,44])

Antioxidant properties of UA Several clinical studies have found a relationship between high levels of UA and endothelial damage (the first critical step towards developing atherosclerosis), hypertension, and cardiovascular disease due to the pro-oxidative properties of UA

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Biol Trace Elem Res 107(3):231