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For example, TRPV1, an ionchannel involved in heat nociception and present on the innervated nerves has been shown to be responsible for NGFreceptor (trkA)mediated remodeling in DRG neurons ex vivo

[PubMed: 10486277] 74

Overproduction of ROS is involved in the pathogenesis of acne vulgaris via various pathways, including activation of mTOR, peroxisome proliferator-activated receptors (PPARs), and toll-like receptors (TLRs) (176178)