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doi: 10.3389/fimmu.2024.1503087 Received 28 September 2024 Accepted 09 December 2024 Published 24 December 2024 Volume 15 - 2024 Edited by Jiaheng Xie, Central South University, China Reviewed by Chunying Li, Georgia State University, United States Yan Shen, Chongqing University of Technology, China Updates Copyright 2024 Chen, Xu, Han, Ding, Ren, Wang, Ma and Cao

Maureen Bigger, CFP Maureen is an investment advisor representative with Chesapeake Investment Management as well as the founder and owner of Bigger & Company, LLC, an insurance brokerage firm

10.1002/slct.202204841 61 GaneshkumarM.SathishkumarM.PonrasuT.DineshM

Th1 and Th17 cytokines activate microglia, increase oxidative stress, and impair neural resilience, whereas Treg deficiency eliminates a crucial control on systemic and central inflammation, promoting a feed-forward degenerative cycle [82]