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SKU: 61377457419
Price: 28.88 USD
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The accumulation factor (equation [7]) assumes that the drug follows a one-compartment model ( Figure 32 B), and the peak concentration prediction assumes that the absorption rate is much faster than the elimination rate

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Oxidative stress, assessed via the GSH/GSSG ratio, increased in both HepG2 and HepG2 ATP7B-KO cells across all copper doses

Repeated dosing studies in rats, dogs, and mice for up to 6 weeks across doses from 0.006 mg/kg to 20 mg/kg via multiple routes showed excellent tolerance