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Pereira C, Gracio D, Teixeira JP, Magro F

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43 , 44 Therefore, certain compounds reduced HIF-1 transcription by (i) preventing the phosphorylation of HIF-1, which affects its movement from the cytoplasm to the nucleus, (ii) inhibiting the interaction between Hsp90 and HIF-1, (iii) interfering with the mitochondrial ETC, (iv)inhibiting protein synthesis, and (v) destabilizing proteins [Figure 2]