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92,93 Researchers found that PCAF-mediated K323 acetylation of PGK1 enhances its enzymatic activity and glucose uptake, elevating liver cancer cell proliferation, and tumorigenesis

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As further proof of concept, the adapted assay was employed in a pilot screen using the LOPAC 1280 compound library

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[DOI] [PubMed] [Google Scholar] 16.Jiang BH, Semenza GL, Bauer C & Marti HH Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension