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Epub 2022 Mar 1

Inflammation and Wnt signaling: target for immunomodulatory therapy

Gene alignment statistics were calculated using feature Counts with paired-end counting, followed by the computation of fragments per kilobase million (FPKM) values for each gene to estimate gene expression levels

The activation phase, the second step in the canonical pathway, is driven by diverse stimuli such as K + efflux, ROS overproduction, lysosomal rupture, mitochondrial DNA (mtDNA) leakage, and organelle dysfunction (e.g., mitochondria, Golgi apparatus, endoplasmic reticulum) (Santos et al., 2018), which can be recognized by caspase-11 (the mouse homolog of human caspase-4/5)