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Description

Matsumura, J.L

J.KangH

A., Lizasoain, I

5mTHF-mediated inhibition has been demonstrated in vitro to involve the GNMT N-terminus, a highly conserved domain composed of a flexible tail (residues 1-8) followed by a structured U-loop (residues 9-22) proximal to the globular domain and SAM binding site, the latter of which functions as a gatekeeper for SAM entry 35,36