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Pre-clinical studies therefore typically employ moderately hypofractionated or ablative regimens (Demaria and Formenti, 2012

reported that social isolation, an often used psychosocial stress paradigm, results in an altered response to a NMDA receptor non-competitive antagonist (ketamine) challenge in mice, namely an exacerbated ketamine-induced glutamine increase and a reduction of GABA concentration in the prefrontal cortex [71]

However, at sub-threshold levels, they may enhance wine complexity (Siebert et al., 2009)

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