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The pivotal trials enrolled hundreds of subjects and used CT-measured visceral adipose tissue (VAT) as the primary endpoint, a harder measure than BMI or waist circumference

It is commonly used in studies focused on endocrine signaling, receptor interaction, and hormone pathway modeling

The body produces a wide range of peptide hormones, which circulate in the blood and bind to receptors on targeted organs and tissues

Metabolic effects of a growth hormonereleasing factor in patients with HIV

Although the MIRAD trial used a NT-proBNP cut-of previously validated in type 2 diabetes [23], the cut-of is lower than what is currently used in HFpEF and HFrEF trials [32], and the resultant low proportion of diastolic dysfunction may reduce the studys ability to detect a clinically relevant difference given the size and duration of the trial despite using high-dose therapy