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Hemolysis: Disorders such as hereditary spherocytosis, sickle cell disease, or autoimmune hemolytic anemia can lead to chronic hemolysis and subsequent iron overload

While theres no definite cutoff for when B12 starts to become unsafe, because people often ask, well somewhat arbitrarily say not to take more than 1,000 g per day over the long-term without guidance from a physician

they're the ones that identify the exact culprit

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They represent opposite ends of the aggression spectrum in fat reduction research