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data analysis and drafting of the manuscript (ZH), critical revision of the manuscript for important intellectual content (ZH, HX, YC, JWPY, YX)

Estrogen plays a key protective role in the development of obesity and metabolic diseases by regulating various metabolic processes, including glucose and lipid metabolism, body weight, adipose tissue distribution, caloric intake, and energy expenditure (Ribas et al., 2010)

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On days 1 and 3 post-adjuvant treatment, 15 g of vCD44BPFc, hTRAILFc or PBS were administered by subcutaneous injection adjacent to the adjuvant + OVA injection site