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Free radicals are generated through several different pathways, e.g., during mitochondrial aerobic respiration, approximately 12% of electrons may escape the electron transport chain, and an estimated 2% of the oxygen consumed by mitochondria contributes to ROS formation, primarily the superoxide radical [25]

We detected rapid and sustained increase in 4-HNE from 1 day to 5 weeks post-SCI in mice

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