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To enhance macrophage uptake, we proactively modified HSA carriers with mannose motifs

Six driver genes were identified in the MVI-positive group: four tumor suppressor genes (TP53, ALB, TSC2, and BRD7) and two oncogenes (CTNNB1 and MMP17)

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In vivo evaluation in H1299 tumor-bearing BALB/c nude mice ( n = 5 per group) receiving peritumoral injections every three days for three weeks revealed potent tumor growth inhibition, with the co-delivery group showing minimal tumor volume increase during the third week compared to substantial growth in the DT2216-only group