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Research applications Research applications In vitro assays of ECM regulation (collagen, elastin) and MMP/TIMP balance Cell migration, proliferation, and cellular migration and tissue-matrix development models (fibroblasts, keratinocytes) Anti-inflammatory and antioxidant signaling studies (NF-B, Nrf2 pathways) Copper-dependent enzymatic and metalloregulator investigations Mechanistic combination studies with growth factors, cytokines, or small molecules For laboratory research use only

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[225] developed CDs using electrolysis synthesis methods capable of detecting dopamine with an LOD of 6 10 8 mol L 1

Mn absorption occurs primarily in the small intestine, with relatively small amounts of Mn derived from the enterohepatic circulation and reabsorption via the renal tubules, thus maintaining systemic Mn balance 26,27