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Fakhar et al

A mouse strain deficient in the common chain, CD131, shared by the IL-3, GM-CSF, and IL-5 receptors have reduced lung eosinophilia in asthma models,12 whereas mice deficient in both CCL11 and IL-5 have even greater reduction in tissue eosinophils in asthma models.13 The highly eosinophil-specific expression of eosinophil peroxidase (EPO) has been exploited for the development of an eosinophil-deficient mouse (so-called PHIL mice, eosinoPHIL minus eosino mice) in which expression of a toxin is molecularly linked to EPO expression, resulting in eosinophil death before they leave the bone marrow.14 These eosinophil-less mice have subsequently been employed in various disease models, including asthma

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LegaardGELyngbaekMPPAlmdalTPDurrerCGNystrupULarsenELet al

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