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Clinical illustration 2: personalized creatine supplementation in post-viral fatigue syndrome A recent parallel-group, randomized, double-blind, placebo-controlled trial [83] evaluated the effects of six months of creatine monohydrate supplementation (4 g/day) in twelve adults aged 1865 years with persistent post-COVID-19 fatigue syndrome (PVFS)a complex condition characterized by mitochondrial dysfunction despite unremarkable results on standard clinical assessments

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Hum Mol Genet 25(3):584596 Giordano L, Deceglie S, d'Adamo P, Valentino ML, La Morgia C, Fracasso F, Roberti M, Cappellari M, Petrosillo G, Ciaravolo S, Parente D, Giordano C, Maresca A, Iommarini L, Del Dotto V, Ghelli AM, Salomao SR, Berezovsky A, Belfort R Jr, Sadun AA, Carelli V, Loguercio Polosa P, Cantatore P (2015) Cigarette toxicity triggers Lebers hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways

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