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For imaging studies, tumors were allowed to grow to approximately 500 mm 3

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Adverse events occurred at similar rates in both groups

Silencing of the GTP-SCS in the INS-1 832/13 cells or in isolated rat islets impaired GSIS by 50% accompanied by an impaired glucose-stimulated increase in the level of cytosolic Ca 2+ which, in turn, inhibits insulin secretion [63]